|
Symbol Name ID |
Cd40
CD40 antigen MGI:88336 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased circulating IgA level |
Increased circulating IgA level |
Decreased circulating IgE |
Decreased circulating IgG level |
Increased circulating IgG level |
Increased circulating IgM level |
Decreased circulating antibody level |
Paraproteinemia |
Impaired Ig class switch recombination |
Impaired memory B cell generation |
Gastrointestinal hemorrhage |
Abnormal bone marrow cell morphology |
Anemia |
Hemolytic anemia |
Neutropenia |
Decreased proportion of CD4-positive helper T cells |
Leukopenia |
Thrombocytopenia |
Lymphoma |
Non-Hodgkin lymphoma |
B-cell lymphoma |
Burkitt lymphoma |
Multiple myeloma |
Elevated erythrocyte sedimentation rate |
Abnormality of the spleen |
Splenomegaly |
| Disease(s) Associated with CD40 | ||||||||||||||||||||||||||
| Burkitt lymphoma | ||||||||||||||||||||||||||
| follicular lymphoma | ||||||||||||||||||||||||||
| immunodeficiency with hyper IgM type 3 | ||||||||||||||||||||||||||
| multiple myeloma | ||||||||||||||||||||||||||
| non-Hodgkin lymphoma | ||||||||||||||||||||||||||
| rheumatoid arthritis | ||||||||||||||||||||||||||
| systemic lupus erythematosus |
| Mouse Phenotypes | hematopoietic system phenotype |
decreased neutrophil cell number |
absent germinal center B cells |
decreased B cell number |
absent spleen germinal center |
decreased spleen germinal center number |
decreased spleen germinal center size |
abnormal immunoglobulin level |
decreased IgA level |
decreased IgE level |
decreased IgG1 level |
decreased IgG2a level |
decreased IgG2b level |
decreased IgG3 level |
increased IgG3 level |
decreased IgG level |
decreased IgM level |
increased IgM level |
decreased immunoglobulin level |
decreased platelet aggregation |
|
| Availability | Mouse Genotype | ||||||||||||||||||||
| Cd40m2Btlr/Cd40m2Btlr | |||||||||||||||||||||
| Cd40tm1Arah/Cd40tm1Arah | |||||||||||||||||||||
| Cd40tm1Geha/Cd40tm1Geha | |||||||||||||||||||||
| Cd40tm1Kik/Cd40tm1Kik | * | ||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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